Role of 17 Beta Estradiol in Etiology of Premenstrual Syndrome in Medical Students

  • Sadaf Saeed Demonstrator, Department of Biochemistry, University Medical & Dental College (UMDC), Faisalabad
  • Muhammad Saeed Professor of Biochemistry, University Medical & Dental College (UMDC), Faisalabad
  • Aysha Azhar Associate Professor, Postgraduate Research Laboratory (PGRL), The University of Faisalabad (TUF), Faisalabad
  • Adnan Saeed Emergency Medical Officer, DHQ Hospital, Faisalabad Pakistan
Keywords: PMS, 17 beta estradiol, PMDD, Luteal Phase, ELISA


Objective: To calculate the incidence of PMS (premenstrual syndrome) in young medical female students. To check relation of serum 17β estradiol with affective symptoms of PMS. Study Design: Cross sectional study. Settings: The Department of Biochemistry, The University of Faisalabad (TUF). Duration: 3 months from September 2017 to November 2017. Methodology: The study groups included 50 controls and 31 patients of the age group 18-28 years. Their symptoms of PMS were noted by questionnaire. Blood sampling of participants was performed in luteal phase of cycle. Serum 17β estradiol was estimated with the help of ELISA. Results: The T-test was used to consider a comparison between the affective symptoms of PMS in patients and controls and for comparison of estradiol between the both groups. While comparing estradiol between the both groups, P value is non-significant. For the symptoms of PMS, P value was significant between patients and control group. Conclusion: It suggests that the fluctuations in serum estradiol level are not the only cause of affective symptoms of PMS in this study. There may be other factors responsible for the symptoms in selected subjects such as life style, dietary habits or genetics.