Association of Dieting, Physical Activity and Lipid Profile with Cholelithiasis in Young Women

  • Nabeela Faisal Senior Demonstrator, Biochemistry University Medical & Dental College, Faisalabad-Pakistan
  • Muhammad Saeed Principal UMDC, Pro Rector, The University of Faisalabad-Pakistan
  • Muhammad Faisal Bilal Lodhi Registrar / Professor of Surgery, Faisalabad Medical University, Faisalabad
Keywords: Cholelithiasis, Dieting, Physical activity, Dyslipidemia


Introduction: Cholelithiasis is becoming very prevalent in the society. A dramatic change is seen in the presentation of the diseases due to change in dietary habits and physical inactivity due to use of social media. Young females (20- 40 years) are increasingly being affected by gallstones due to craving for fast food on one hand and strong desire to be smart on the other hand. Objectives: This study aimed at identification of modifiable risk factors like dieting/weight loss and physical activity in young females suffering from gallstone disease and to define the role of serum HDL and LDL in the causation of cholelithiasis. Study Design: Cross -sectional Study. Settings: Surgical unit I of Allied Hospital, Faisalabad Medical University (FMU), Faisalabad. Duration: 20-6-2017 to 20-10-2017. Methodology: A total of 80 participants were included in the study; 50 patients of gallstones and 30 controls having same age (20-40 years). A literature-based questionnaire regarding nature of dieting and physical activity was used to collect the data. Serum HDL was assayed by kit method using automated analyzer and serum LDL was calculated using Frield Wald’ Equation. Abdominal ultrasonography for both patients and controls were performed. Statistical analysis was done on the obtained data using SPSS version 17. Results: A p value less than 0.05 was considered as significant. Out of 80 participants, 6(12%) patients and 4(13.3%) controls gave history of dieting. While the remaining 44(88%) patients and 26(86.7%) controls had no previous history of dieting. Only 7(14%) patients and 3(10%) controls had history of physical activity whereas 43(86%) patients and 27(90%) controls gave history of sedentary lifestyle. Raised LDL was found in 27(54%) patients and 8(26.7%) controls. Normal level was seen in 23(46%) patients and 22(73.3%) controls. Decreased HDL was observed in 45(90%) patients and 25(83.3%) controls. Normal HDL was found in 5(10%) patients and 5(16.7%) controls. Conclusion: No association was found with dieting and physical inactivity. There is strong correlation of the disease with raised LDL. Also, no correlation was found with decreased HDL.