Frequency of Luminal A and Luminal B Breast Cancers in Pakistani Population

Sadia Alam; Sabiha Riaz; Haseeb Ahmed Khan; Atiya Batool Gardezi; Khurram Shehzad; Muhammad Fayyaz Anwar

doi:10.29054/apmc/2019.761

Sadia Alam Resident Doctor of Pathology Department FMH College of Medicine & Dentistry, Lahore Pakistan
Sabiha Riaz Professor of Pathology Department FMH College of Medicine & Dentistry, Lahore Pakistan
Haseeb Ahmed Khan Assistant Professor of Pathology Department, FMH College of Medicine & Dentistry, Lahore Pakistan
Atiya Batool Gardezi Resident Doctor, Pathology Department FMH College of Medicine & Dentistry, Lahore Pakistan
Khurram Shehzad Post Graduate Resident Doctor, Pathology Department FMH College of Medicine & Dentistry, Lahore Pakistan
Muhammad Fayyaz Anwar Assistant Professor of Pathology Department Lahore General Hospital, Lahore Pakistan

DOI: https://doi.org/10.29054/apmc/2019.761

Keywords: Breast cancer, ER, PR, Ki67, Luminal, Immunohistochemistry

Abstract

Objective: To measure frequency of Luminal A and Luminal B breast cancers in hormone receptor positive cancers in Pakistani population. Study Design: Descriptive, Cross Sectional Survey. Settings: Pathology department, Fatima Memorial Hospital, Lahore. Duration: July 2016 to January 2017. Methodology: 110 cases of hormone receptor positive breast cancers were subclassified into luminal A and luminal B breast cancers by using immunohistochemical stain Ki67. The cut-off value of ki67 in our study was set as 14%. The selected cases were ER and PR positive which was determined by doing the immunohistochemical stain ER and PR and these cases were further subjected to the proliferation index marker ki67. The hematoxylin and eosin slides along with the immunohistochemical stains were interpreted by histopathologist. The collected information was analyzed by using computer software SPSS version 18. Results: The frequency of luminal A was 37% and luminal B as 63%. Age range was 22 to 80 years with an average of 49 years. Maximum number of cases were seen within range of 41 to 50 years. Ductal carcinoma was the most common subtype followed by lobular breast carcinoma. Grade 3 cancers constituted more than 50% of total cases. 48.8% of luminal A and 66.7% of luminal B cancers were grade 3 cancers. Conclusion: Frequency of luminal B breast cancer is greater than luminal A cancers in Pakistani population.