Diabetes Mellitus in Hepatitis C Patients Presenting to Tertiary Care Facility, Nawabshah
Background: Increased incidence has been found for diabetes and hepatitis C. The most common mechanism involved is the insulin resistance that interferes in hepatocytes with insulin signaling and cause inflammatory mediators release with increasing oxidative stress. Objective: To determine the frequency of diabetes mellitus in Hepatitis C patients presenting to tertiary care facility, Nawabshah. Study Design: Cross Sectional Study. Settings: Medicine Department of People’s University of Medical & Health Sciences for Women Nawabshah District Shaheed Benazirabad, Sindh-Pakistan. Duration: From 4th August 2016 to 3rd February 2017. Methodology: Total 137 patients with HCV RNA seropositive, diagnosed by PCR with or without liver cirrhosis of duration more than 2 years and either of gender were included. Patients were diagnosed for diabetes mellitus if Glycated hemoglobin (HbA1C) ≥ 6.5%. Data was collected via self-made proforma. Results: There were 72 male and 65 female subjects. Mean age was 43.75±10.55 years. Mean HBA1C was 6.53±0.60%. Mean duration of HCV was 4.71±0.96 years. 59.1% patients have liver cirrhosis. Diabetes mellitus was observed in 45(32.8%) cases. Significant correlation of liver cirrhosis, gender, and age was observed with diabetes among HCV patients. While no significant correlation was found with duration of HCV. Conclusion: Type 2 diabetes mellitus was observed high (32.8%) among hepatitis C positive patients.