Diagnostic Accuracy of Contrast Enhanced Computed Tomography in Detection of Ovarian Cancer in Clinically Suspected Patients

  • Gulzar Bhund Consultant Radiologist, National Medical Center Hospital, Karachi-Pakistan
  • Abid Ali Sahito Assistant Professor, Radiology Bilawal Medical College, LUMHS Jamshoro Pakistan
  • Mohsin Hussain Khoso Senior Registrar, Pir Abdul Qadir Shah Jilani Institute of Medical Science Gambat Khairpur Pakistan
  • Sasui Memon Consultant Radiologist, Advance Diagnostic Center, Bilawal Medical College, LUMHS Jamshoro Pakistan
  • Hafeez ur Rehman Senior Registrar, Indus Medical College Hospital Tando Muhammad Khan Pakistan
  • Ahsan Ullah Consultant Radiologist Matiari Health Services, Matiari Pakistan
Keywords: Diagnostic Accuracy, Contrast Enhanced Computed Tomography, Ovarian Cancer

Abstract

Background: In the gynecologic malignancies, ovarian cancer is the 2nd most common and a big cause of the mortality. Contrast-enhanced CT is a recent imaging technique of choice in preoperative assessment of ovarian cancer. Objective: To determine the diagnostic accuracy of contrast enhanced computed tomography of abdomen and pelvis in detection of ovarian cancer in clinically suspected patients by using histopathology as gold standard. Study Design: Cross-Sectional Study. Settings: Department of Radiology Civil Hospital, Karachi Pakistan. Duration: Six months from 26th April to 25th October 2017. Methodology: All the clinically suspected patients of ovarian cancer were included. Contrast Enhanced Computed Tomography (CECT) of pelvis and abdomen was performed with injection of intravenous contrast material. The CECT, diagnostic accuracy was established in terms of sensitivity, specificity, PPV, NPV against histopathology. By taking p-value ≤ 0.05 as significant, chi square test (post stratification) was applied. Results: The mean age of patients was 31.84±7.95 years. Mean duration of symptoms was 13.37±5.99 weeks. Serum cancer antigen-125 level was 62.23±14.66 U/ml. Total 27.5% subjects were diagnosed with ovarian cancer by contrast enhanced CT and 29.6% by Histopathology. Specificity, Sensitivity, NPV, PPV, and accuracy were 86.7%, 97.4%, 93.4%, 94.5%, and 94.2% respectively. Conclusion:  The contrast enhanced computer tomography is helpful diagnostic tool to detect the ovarian cancer, with accuracy rate of 94.2%, 86.7% sensitivity and 97.4% specificity.

Published
2020-03-31